With our advanced technologies, team of talented scientists and decades of experience in medical diagnostics and research, the Centre stands in a strong position to provide professional and high quality services in various areas of medical sciences. These services include but are not limited to:
Pathogen detection
Immunological assays
Genomic services
Molecular Biology & Biotechnology Studies Centre is an ISO accredited facility and benefits from an isolated containment level 3 facility for processing highly contagious pathogens.
Molecular based methods have advanced the centre testing to faster and better diagnostics. PCR methods, microarray and next generation sequencing have provided speed and high level of accuracy. Molecular biology based methods are sensitive and quick to detect microbial pathogens in various clinical specimens. We offer molecular detection of pathogenic viruses, bacteria and parasites from clinical specimens. Molecular Biology & Biotechnology Studies Centre accredited and benefits from a stand-alone containment Level 3 facility where samples for highly contagious pathogen are received and processed.
The advancement of sequencing technologies, computational science and database contributed to the unexpected leap in knowledge of the human genome that plays a vital role in predicting, preventing and diagnosing of diseases. The houses two next generation sequencers enabling the centre to expand its repertoire of services into areas such as meta-genomics, whole genome and exome sequencing along with high throughput targeted panel sequencing. Molecular Biology & Biotechnology Studies Centre benefits from high-performance computing (HPC) infrastructure and validated in-house pipelines to process and assist in interpreting the immense genomic sequence data, rapidly and accurately.
The advancement of sequencing technologies, computational science and database contributed to the unexpected leap in knowledge of the human genome that plays a vital role in predicting, preventing and diagnosing of diseases. The houses two next generation sequencers enabling the centre to expand its repertoire of services into areas such as meta-genomics, whole genome and exome sequencing along with high throughput targeted panel sequencing. Molecular Biology & Biotechnology Studies Centre benefits from high-performance computing (HPC) infrastructure and validated in-house pipelines to process and assist in interpreting the immense genomic sequence data, rapidly and accurately.
Immunology is the latest addition to the expanding portfolio of Immunologic tests employ an antigen to detect presence of antibodies to a pathogen, or an antibody to detect the presence of an antigen, of the pathogen in the specimens of the patient. At Molecular Biology & Biotechnology Studies Centre, we use ECL (Electrochemiluminescence) technology for immunoassay detection, which results in high sensitivity and specificity.
Stem cell research and Cytogenetics have been utilized for years to help understand cell and tissue regeneration as well as how chromosomal abnormalities and genetic diseases occur. We in Molecular Biology & Biotechnology Studies Centre provide dependable, high-quality results with fast turnaround time by microscopic visualizing of the chromosomes allowing our clients to identify the presence of any chromosomal anomalies such as deletions, inversions, and duplications.
Cytogenetics provides the basis for identification, analysis, and understanding of chromosome configuration and behavior within a species that may be of economic and/or scientific interest.
Chromosome analysis provides a "bird’s eye view" of an individual's genetic information. Missing, extra, or rearranged chromosome material may be responsible for diverse problems such as birth defects, mental retardation, autism, infertility, and repeated miscarriage in humans. Chromosome karyotypes are prepared from lymphocytes of peripheral blood or tissue fibroblasts which have been isolated and cultured under proper laboratory conditions. These cells are then characterized by using a special imaging microscope. Analysis of numerical, by counting to ensure that the cells evaluated have the correct number of chromosomes, and structural, to ensure that there are no large pieces of material that are missing (deleted), extra (duplicated), or any rearranged.
It is important to realize that standard chromosome analysis may not be able to detect tiny deletions or duplications of genetic material, and will not be able to detect single-gene mutations.
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology is a relatively facile method for editing genes. Editing allows researchers to elucidate the function of genes, leading to new products and procedures with benefits to human health and well-being. Gene-edited cells are a useful tool for understanding disease processes and how we might intervene. The genes of these cells may be overexpressed, knocked-out, or otherwise edited in various ways to mimic diseased cells that will respond to experimental treatment as would the tissues being modelled. The Genome Editing Core Facility offers a suite of services to support researchers who use these kinds of cells:
Design and cloning of customized plasmids for lentiviral vector production
Lentiviral packaging and production for gene knockdown and overexpression
Customized cloning for CRISPR-based genome editing
On-site lentiviral transduction (BSL2 cell culture facility required)
Consultation on design of lentiviral vector and genome editing tools
Access to facility instrumentation and plasmid library